CtcS, a MarR family regulator, regulates chlortetracycline biosynthesis.

ABSTRACT:

Background

Chlortetracycline (CTC) is one of the commercially important tetracyclines (TCs) family product and is mainly produced by Streptomyces. CTC is still in a great demand due to its broad-spectrum activity against pathogens. Engineering transcriptional control allows the cell to allocate its valuable resources towards protein production and provides an important method for the build-up of desired metabolites. Despite extensive efforts concerning transcriptional regulation for increasing the productivities of TCs, the regulatory mechanisms of the CTC biosynthesis remain poorly understood.

Results

In this study, the possible regulatory function of CtcS, a potential member of MarR (multiple antibiotic resistance regulator) family of transcriptional regulators in S. aureo

SUBMITTER: Kong L 

PROVIDER: S-EPMC6905112 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature