Alteration of functional connectivity in patients with Alzheimer's disease revealed by resting-state functional magnetic resonance imaging.

ABSTRACT: The main symptom of patients with Alzheimer's disease is cognitive dysfunction. Alzheimer's disease is mainly diagnosed based on changes in brain structure. Functional connectivity reflects the synchrony of functional activities between non-adjacent brain regions, and changes in functional connectivity appear earlier than those in brain structure. In this study, we detected resting-state functional connectivity changes in patients with Alzheimer's disease to provide reference evidence for disease prediction. Functional magnetic resonance imaging data from patients with Alzheimer's disease were used to show whether particular white and gray matter areas had certain functional connectivity patterns and if these patterns changed with disease severity. In nine white and corresponding gray matt

SUBMITTER: Zhao J 

PROVIDER: S-EPMC6905343 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature