IL-4/IL-13 polarization of macrophages enhances Ebola virus glycoprotein-dependent infection.

ABSTRACT:

Background

Ebolavirus (EBOV) outbreaks, while sporadic, cause tremendous morbidity and mortality. No therapeutics or vaccines are currently licensed; however, a vaccine has shown promise in clinical trials. A critical step towards development of effective therapeutics is a better understanding of factors that govern host susceptibility to this pathogen. As macrophages are an important cell population targeted during virus replication, we explore the effect of cytokine polarization on macrophage infection.

Methods/main findings

We utilized a BSL2 EBOV model virus, infectious, recombinant vesicular stomatitis virus encoding EBOV glycoprotein (GP) (rVSV/EBOV GP) in place of its native glycoprotein. Macrophages polarized towards a M2-like anti-inflammatory state by combined IL-4

SUBMITTER: Rogers KJ 

PROVIDER: S-EPMC6905523 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature