The projected impact of geographic targeting of oral cholera vaccination in sub-Saharan Africa: A modeling study.

ABSTRACT: BACKGROUND:Cholera causes an estimated 100,000 deaths annually worldwide, with the majority of burden reported in sub-Saharan Africa. In May 2018, the World Health Assembly committed to reducing worldwide cholera deaths by 90% by 2030. Oral cholera vaccine (OCV) plays a key role in reducing the near-term risk of cholera, although global supplies are limited. Characterizing the potential impact and cost-effectiveness of mass OCV deployment strategies is critical for setting expectations and developing cholera control plans that maximize the chances of success. METHODS AND FINDINGS:We compared the projected impacts of vaccination campaigns across sub-Saharan Africa from 2018 through 2030 when targeting geographically according to historical cholera burden and risk factors. We assessed the nu

SUBMITTER: Lee EC 

PROVIDER: S-EPMC6905526 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature