Serum PCSK6 and corin levels are not associated with cardiovascular outcomes in patients undergoing coronary angiography.

ABSTRACT: INTRODUCTION:Proprotein convertase subtilisin/kexin-6 (PCSK6) is a secretory protein that activates corin in the heart. Higher circulating levels of corin are associated with improved cardiovascular outcomes in patients with acute myocardial infarction. This study aimed to determine the role of serum PCSK6 and corin levels in predicting cardiovascular outcomes in patients with suspected coronary artery disease (CAD). MATERIALS AND METHODS:In total, 565 patients who had undergone coronary angiography were enrolled. Serum PCSK6 and corin levels were determined before the administration of contrast media. In this study, coronary revascularization, acute myocardial infarction, acute stroke, and death were defined as cardiovascular outcomes. All patients were followed up for at least one year a

SUBMITTER: Yang SF 

PROVIDER: S-EPMC6905542 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature