Effects of treatment with enrofloxacin or tulathromycin on fecal microbiota composition and genetic function of dairy calves.

ABSTRACT: The increasing concerns with antimicrobial resistance highlights the need for studies evaluating the impacts of antimicrobial use in livestock on antimicrobial resistance using new sequencing technologies. Through shotgun sequencing, we investigated the changes in the fecal microbiome composition and function, with a focus on functions related to antimicrobial resistance, of dairy calves. Heifers 2 to 3 weeks old, which were not treated with antibiotics by the farm before enrollment, were randomly allocated to one of three study groups: control (no treatment), a single treatment of enrofloxacin, or a single treatment of tulathromycin. Fecal samples were collected at days 4, 14, 56 and 112 days after enrollment, and DNA extraction and sequencing was conducted. The effect of antibiotic treat

SUBMITTER: Foditsch C 

PROVIDER: S-EPMC6905572 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature