Role of extracellular matrix in the biomechanical behavior of pancreatic tissue.

ABSTRACT: Correlating the biomechanical properties of tissue with its function is an emerging area of research with potential impact in diagnostics, therapeutics, and prognostics. A critical stepping-stone in developing structure-function models is creating methods that can correlate the tissue structure with its mechanical behavior. As an initial step in addressing this challenge, we have characterized the mechanical behavior of unprocessed pancreatic tissue using optical fiber polarimetric elastography. To correlate the observed behavior to physiologically relevant structural features, a series of architectures are designed and fabricated using 3D printing. The mechanical response of the 3D printed elastomeric structures is analyzed using compressive testing and modeled using finite element analys

SUBMITTER: Hudnut AW 

PROVIDER: S-EPMC6905626 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature