Analysis of generalized semiparametric mixed varying-coefficients models for longitudinal data.

ABSTRACT: The generalized semiparametric mixed varying-coefficient effects model for longitudinal data can accommodate a variety of link functions and flexibly model different types of covariate effects, including time-constant, time-varying, and covariate-varying effects. The time-varying effects are unspecified functions of time and the covariate-varying effects are nonparametric functions of a possibly time-dependent exposure variable. A semiparametric estimation procedure is developed that uses local linear smoothing and profile weighted least squares, which requires smoothing in the two different and yet connected domains of time and the time-dependent exposure variable. The asymptotic properties of the estimators of both nonparametric and parametric effects are investigated. In addition, hypot

SUBMITTER: Sun Y 

PROVIDER: S-EPMC6905629 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature