Novel genetic loci affecting facial shape variation in humans.

ABSTRACT: The human face represents a combined set of highly heritable phenotypes, but knowledge on its genetic architecture remains limited, despite the relevance for various fields. A series of genome-wide association studies on 78 facial shape phenotypes quantified from 3-dimensional facial images of 10,115 Europeans identified 24 genetic loci reaching study-wide suggestive association (p < 5 × 10^-8), among which 17 were previously unreported. A follow-up multi-ethnic study in additional 7917 individuals confirmed 10 loci including six unreported ones (p_adjusted < 2.1 × 10^-3). A global map of derived polygenic face scores assembled facial features in major continental groups consistent with anthropological knowledge. Analyses of epigenomic datasets from cranial ne

SUBMITTER: Xiong Z 

PROVIDER: S-EPMC6905649 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature