Disrupted resting-state brain functional network in methamphetamine abusers: A brain source space study by EEG.

ABSTRACT: This study aimed to examine the effects of chronic methamphetamine use on the topological organization of whole-brain functional connectivity network (FCN) by reconstruction of neural-activity time series at resting-state. The EEG of 36 individuals with methamphetamine use disorder (IWMUD) and 24 normal controls (NCs) were recorded, pre-processed and source-reconstructed using standardized low-resolution tomography (sLORETA). The brain FCNs of participants were constructed and between-group differences in network topological properties were investigated using graph theoretical analysis. IWMUD showed decreased characteristic path length, increased clustering coefficient and small-world index at delta and gamma frequency bands compared to NCs. Moreover, abnormal changes in inter-regional con

SUBMITTER: Khajehpour H 

PROVIDER: S-EPMC6906079 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature