The Aquaporin 5 -1364A/C Promoter Polymorphism Is Associated With Cytomegalovirus Infection Risk in Kidney Transplant Recipients.

ABSTRACT: Background: The aquaporin 5 (AQP5) -1364A/C promoter single nucleotide polymorphism affects key mechanisms of inflammation and immune cell migration. Thus, it could be involved in the pathogenesis of cytomegalovirus infection. Accordingly, we tested the hypothesis that the AQP5 promoter -1364A/C polymorphism is associated with the risk of cytomegalovirus infection in kidney transplantation recipients. Methods: We included 259 adult patients who received a kidney transplant from 2007 and 2014 in this observational study. Patients were genotyped for the AQP5 promoter -1364A/C single nucleotide polymorphism and followed up for 12 months after transplantation. Kaplan-Meier plots and multivariable proportional hazard analyses were used to evaluate the relation

SUBMITTER: Rahmel T 

PROVIDER: S-EPMC6906153 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature