Centre effects and case-mix in early rheumatoid arthritis observational cohorts: a narrative review.

ABSTRACT:

Objectives

Observational cohort studies in early RA are a key source of evidence, despite inconsistencies in methodological approaches. This narrative review assesses the spectrum of methodologies used in addressing centre-level effect and case-mix adjustment in early RA observational cohort studies.

Methods

An electronic search was undertaken to identify observational prospective cohorts of >100 patients recruited from two or more centres, within 2 years of an RA or early inflammatory arthritis diagnosis. References and author publication lists of all studies from eligible cohorts were assessed for additional cohorts.

Results

Thirty-four unique cohorts were identified from 204 studies. Seven percent of studies considered centre in their analyses, most commonly as a f

SUBMITTER: Yates M 

PROVIDER: S-EPMC6906213 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature