IgE binding to linear epitopes of Ara h 2 in peanut allergic preschool children undergoing oral Immunotherapy.

ABSTRACT:

Background

For patients with peanut allergy, there are currently no methods to predict who will develop sustained unresponsiveness (SU) after oral immunotherapy (OIT).

Objective

Assess IgE binding to peanut (PN), Ara h 2, and specific linear epitopes of Ara h 2 as predictors of the important clinical parameters: eliciting dose threshold and attainment of SU following OIT.

Methods

Samples and clinical data were collected from children undergoing OIT. PN- and Ara h 2-sIgE were quantified by ImmunoCAP^® . IgE binding to linear peptides of Ara h 2 and Ara h 6 was measured with peptide microarrays.

Results

Values of PN-sIgE correlated with eliciting dose (P = .001) and with a higher likelihood of achieving SU (P < .0001), but these relationships were lost

SUBMITTER: Dreskin SC 

PROVIDER: S-EPMC6906227 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature