Data-driven identification of subtypes of executive function across typical development, attention deficit hyperactivity disorder, and autism spectrum disorders.

ABSTRACT:

Background

Impairment of executive function (EF), the goal-directed regulation of thoughts, actions, and emotions, drives negative outcomes and is common across neurodevelopmental disorders including attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). A primary challenge to its amelioration is heterogeneity in symptom expression within and across disorders. Parsing this heterogeneity is necessary to attain diagnostic precision, a goal of the NIMH Research Domain Criteria Initiative. We aimed to identify transdiagnostic subtypes of EF that span the normal to impaired spectrum and establish their predictive and neurobiological validity.

Methods

Community detection was applied to clinical parent-report measures in 8-14-year-old children with and

SUBMITTER: Vaidya CJ 

PROVIDER: S-EPMC6906253 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature