Plasma metabolomics of early parenteral nutrition followed with enteral nutrition in pancreatic surgery patients.

ABSTRACT: Nutrition support is essential for surgical patients. Patients undergoing pancreaticoduodenectomy (PD) require tremendous nutrient support but also faced with risks of infection and gastrointestinal complications. Early parenteral nutrition has recently shown benefits while limited information provided about the influence on metabolism. This prospective single-center cohort study used plasma metabolomics to clarify metabolic alteration after early parenteral nutrition followed with enteral nutrition. Patients undergoing pancreaticoduodenectomy (n = 52) were enrolled. 36 patients received parenteral nutrition within 3 days postoperatively followed with EN (TPN group), 16 patients received standard fluids followed with EN (GIK group). We found that the weight loss is reduced in TPN group whi

SUBMITTER: Jiang Z 

PROVIDER: S-EPMC6906312 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature