Cranial irradiation mediated spine loss is sex-specific and complement receptor-3 dependent in male mice.

ABSTRACT: Cranial irradiation is the main therapeutic treatment for primary and metastatic malignancies in the brain. However, cranial radiation therapy produces long-term impairment in memory, information processing, and attention that contribute to a decline in quality of life. The hippocampal neural network is fundamental for proper storage and retrieval of episodic and spatial memories, suggesting that hippocampal signaling dysfunction could be responsible for the progressive memory deficits observed following irradiation. Previous rodent studies demonstrated that irradiation induces significant loss in dendritic spine number, alters spine morphology, and is associated with behavioral task deficits. Additionally, the literature suggests a common mechanism in which synaptic elimination via microg

SUBMITTER: Hinkle JJ 

PROVIDER: S-EPMC6906384 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature