CAIX-targeting radiotracers for hypoxia imaging in head and neck cancer models.

ABSTRACT: Hypoxia-induced carbonic anhydrase IX (CAIX) expression is a prognostic marker in solid tumors. In recent years many radiotracers have been developed, but a fair comparison of these compounds is not possible because of the diversity in tumor models and other experimental parameters. In this study we performed a direct in vivo comparison of three promising CAIX targeting radiotracers in xenografted head and neck cancer models. The biodistribution of [¹¹¹In]In-DOTA-ZCAIX:2 was directly compared with [¹¹¹In]In-DTPA-G250-F(ab')₂ and [¹¹¹In] In-DTPA-G250 in female BALB/C nu/nu mice bearing two HNSCC xenografts with different levels of CAIX expression. In vivo biodistribution was quantified by means of microSPECT/CT scans and ex vivo biodistribution wa

SUBMITTER: Huizing FJ 

PROVIDER: S-EPMC6906415 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature