Differential regulation of TRP channel gene and protein expression by intervertebral disc degeneration and back pain.

ABSTRACT: Intervertebral disc (IVD) degeneration and consequent low back pain (LBP) are common and costly pathological processes that require improved treatment strategies. Transient Receptor Potential (TRP) channels constitute a family of multimodal ion channels that have recently emerged as contributors to disc pathologies and were thus proposed as potential therapeutic targets, although limited data on their presence and function in the IVD exist. The purpose of this study was to determine the mRNA and protein expression of TRP channels in non-degenerated and degenerated human IVD tissue (with different pain intensity and chronicity) using gene array, conventional qPCR and immunohistochemistry. We could demonstrate that 26 out of 28 currently known TRP channels are expressed in the IVD on the mRN

SUBMITTER: Sadowska A 

PROVIDER: S-EPMC6906425 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature