Resting-state functional connectivity in women with PMDD.

ABSTRACT:

Background

Premenstrual dysphoric disorder (PMDD) is an understudied, debilitating disorder of women. Given evidence for prefrontal cortical and limbic dysfunction in PMDD, we compared intrinsic connectivity of the executive control network (ECN), default mode network (DMN), and amygdala in women with PMDD vs. controls.

Methods

Thirty-six women (18 PMDD, 18 control) participated in fMRI during the follicular and luteal phases of the menstrual cycle. At each time, resting-state functional connectivity was evaluated both before and after participants performed an emotion regulation task. The ECN was identified using independent components analysis, and connectivity of left and right amygdala seeds was also evaluated.

Results

Nonparametric permutation testing identified

SUBMITTER: Petersen N 

PROVIDER: S-EPMC6906514 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature