Tumour-associated macrophage-derived interleukin-1 mediates glioblastoma-associated cerebral oedema.

ABSTRACT: Glioblastoma is the most common and uncompromising primary brain tumour and is characterized by a dismal prognosis despite aggressive treatment regimens. At the cellular level, these tumours are composed of a mixture of neoplastic cells and non-neoplastic cells, including tumour-associated macrophages and endothelial cells. Cerebral oedema is a near-universal occurrence in patients afflicted with glioblastoma and it is almost exclusively managed with the corticosteroid dexamethasone despite significant drawbacks associated with its use. Here, we demonstrate that dexamethasone blocks interleukin-1 production in both bone marrow-derived and brain resident macrophage populations following stimulation with lipopolysaccharide and interferon gamma. Additionally, dexamethasone is shown to inhibit

SUBMITTER: Herting CJ 

PROVIDER: S-EPMC6906596 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature