Temporal evolution of the microbiome, immune system and epigenome with disease progression in ALS mice.

ABSTRACT: Amyotrophic lateral sclerosis (ALS) is a terminal neurodegenerative disease. Genetic predisposition, epigenetic changes, aging and accumulated life-long environmental exposures are known ALS risk factors. The complex and dynamic interplay between these pathological influences plays a role in disease onset and progression. Recently, the gut microbiome has also been implicated in ALS development. In addition, immune cell populations are differentially expanded and activated in ALS compared to healthy individuals. However, the temporal evolution of both the intestinal flora and the immune system relative to symptom onset in ALS is presently not fully understood. To better elucidate the timeline of the various potential pathological factors, we performed a longitudinal study to simultaneously

SUBMITTER: Figueroa-Romero C 

PROVIDER: S-EPMC6906635 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature