Disentangling brain functional network remodeling in corticobasal syndrome - A multimodal MRI study.

ABSTRACT:

Objective

The clinical diagnosis of corticobasal syndrome (CBS) represents a challenge for physicians and reliable diagnostic imaging biomarkers would support the diagnostic work-up. We aimed to investigate the neural signatures of CBS using multimodal T1-weighted and resting-state functional magnetic resonance imaging (MRI).

Methods

Nineteen patients with CBS (age 67.0 ± 6.0 years; mean±SD) and 19 matched controls (66.5 ± 6.0) were enrolled from the German Frontotemporal Lobar Degeneration Consortium. Changes in functional connectivity and structure were respectively assessed with eigenvector centrality mapping complemented by seed-based analysis and with voxel-based morphometry. In addition to mass-univariate statistics, multivariate support vector machine (SVM) classifica

SUBMITTER: Ballarini T 

PROVIDER: S-EPMC6906725 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature