Aromatic Guanylhydrazones for the Control of Heme-Induced Antibody Polyreactivity.

ABSTRACT: In a healthy immune repertoire, there exists a fraction of polyreactive antibodies that can bind to a variety of unrelated self- and foreign antigens. Apart from naturally polyreactive antibodies, in every healthy individual, there is a fraction of antibody that can gain polyreactivity upon exposure to porphyrin cofactor heme. Molecular mechanisms and biological significance of the appearance of cryptic polyreactivity are not well understood. It is believed that heme acts as an interfacial cofactor between the antibody and the newly recognized antigens. To further test this claim and gain insight into the types of interactions involved in heme binding, we herein investigated the influence of a group of aromatic guanylhydrazone molecules on the heme-induced antibody polyreactivity. From the

SUBMITTER: Bozinovic N 

PROVIDER: S-EPMC6906781 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature