Impaired resolution of wheals in the skin prick test and low diamine oxidase blood level in allergic patients.

ABSTRACT:

Introduction

Histamine is the major mediator of IgE- and non-IgE-mediated allergic reactions upon allergen or hapten contact. Reduced histamine degradation capacity was associated with atopic eczema as well as with non-immunological histamine intolerance. Higher blood serum histamine level concomitant with decreased intestinal diamine oxidase activity were observed in patients with food allergy.

Aim

To evaluate the relationship between patients' blood diamine oxidase (DAO) activity/histamine status and their reactivity to time-resolved histamine skin prick test in respect to vulnerability to allergic diseases.

Material and methods

Fifty-three patients were examined with skin prick tests (SPT) and patch tests for suspected presence of either IgE- or non-IgE-mediated al

SUBMITTER: Wagner A 

PROVIDER: S-EPMC6906969 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature