Identification and Application of Gene Expression Signatures Associated with Lifespan Extension.

ABSTRACT: Several pharmacological, dietary, and genetic interventions that increase mammalian lifespan are known, but general principles of lifespan extension remain unclear. Here, we performed RNA sequencing (RNA-seq) analyses of mice subjected to 8 longevity interventions. We discovered a feminizing effect associated with growth hormone regulation and diminution of sex-related differences. Expanding this analysis to 17 interventions with public data, we observed that many interventions induced similar gene expression changes. We identified hepatic gene signatures associated with lifespan extension across interventions, including upregulation of oxidative phosphorylation and drug metabolism, and showed that perturbed pathways may be shared across tissues. We further applied the discovered longevity

SUBMITTER: Tyshkovskiy A 

PROVIDER: S-EPMC6907080 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature