Antimutagenic components in Spatholobus suberectus Dunn against N-methyl-N-nitrosourea.

ABSTRACT:

Background

An extract from Spatholobus suberectus (S. suberectus) Dunn has been reported to show potent antimutagenic effects against N-alkyl-N-nitrosoureas in umu screening. The aim of this study was to identify the antimutagenic components from extracts of S. suberectus against N-methyl-N-nitrosourea (MNU) in the Ames assay with Salmonella typhimurium strain TA1535 and to elucidate the antimutagenic mechanism of the flavonoids.

Results

From the ethyl acetate fraction obtained from fractionation of the methanol extract of S. suberectus Dunn, medicarpin, formononetin and isoliquiritigenin were successfully isolated through a combination of normal- and reversed-phase chromatography. Genistein and naringenin

SUBMITTER: Inami K 

PROVIDER: S-EPMC6907206 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature