Deviation from normative brain development is associated with symptom severity in autism spectrum disorder.

ABSTRACT:

Background

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition. The degree to which the brain development in ASD deviates from typical brain development, and how this deviation relates to observed behavioral outcomes at the individual level are not well-studied. We hypothesize that the degree of deviation from typical brain development of an individual with ASD would relate to observed symptom severity.

Methods

The developmental changes in anatomical (cortical thickness, surface area, and volume) and diffusion metrics (fractional anisotropy and apparent diffusion coefficient) were compared between a sample of ASD (n = 247) and typically developing children (TDC) (n = 220) aged 6-25. Machine learning was used to predict age (brain age)

SUBMITTER: Tunc B 

PROVIDER: S-EPMC6907209 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature