Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis.

ABSTRACT: Infectious complications in patients with cirrhosis frequently initiate episodes of decompensation and substantially contribute to the high mortality. Mechanisms of the underlying immuneparesis remain underexplored. TAM receptors (TYRO3/AXL/MERTK) are important inhibitors of innate immune responses. To understand the pathophysiology of immuneparesis in cirrhosis, we detailed TAM receptor expression in relation to monocyte function and disease severity prior to the onset of acute decompensation. TNF-α/IL-6 responses to lipopolysaccharide were attenuated in monocytes from patients with cirrhosis (n = 96) compared with controls (n = 27) and decreased in parallel with disease severity. Concurrently, an AXL-expressing (AXL⁺) monocyte population expanded. AXL⁺ cells (CD14

SUBMITTER: Brenig R 

PROVIDER: S-EPMC6907389 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature