Environmental enrichment effects after early stress on behavior and functional brain networks in adult rats.

ABSTRACT: Early life stress is associated with long-term and pervasive adverse effects on neuroendocrine development, affecting normal cognitive and emotional development. Experimental manipulations like environmental enrichment (EE) may potentially reverse the effects of early life stress induced by maternal separation (MS) paradigm in rodents. However, the functional brain networks involved in the effects of EE after prolonged exposure to MS have not yet been investigated. In order to evaluate possible changes in brain functional connectivity induced by EE after MS, quantitative cytochrome c oxidase (CCO) histochemistry was applied to determine regional brain oxidative metabolism in adult male rats. Unexpectedly, results show that prolonged MS during the entire weaning period did not cause any det

SUBMITTER: Gonzalez-Pardo H 

PROVIDER: S-EPMC6907785 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature