Effects of long-term statin-treatment on coronary atherosclerosis in patients with inflammatory joint diseases.

ABSTRACT:

Background

The effect of statins over time on coronary atherosclerosis in patients with inflammatory joint diseases (IJD) is unknown. Our aim was to evaluate the change in coronary plaque morphology and volume in long-term statin-treated patients with IJD.

Methods

Sixty-eight patients with IJD and carotid artery plaque(s) underwent coronary computed tomography angiography before and after a mean of 4.7 (range 4.0-6.0) years of statin treatment. The treatment target for low density lipoprotein cholesterol (LDL-c) was ≤1.8 mmol/L. Changes in plaque volume (calcified, mixed/soft and total) and coronary artery calcification (CAC) from baseline to follow-up were assessed using the 17-segment American Heart Association-model.

Results

Median (IQR) increase in CAC after stati

SUBMITTER: Svanteson M 

PROVIDER: S-EPMC6908439 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature