Slc4a11 disruption causes duct cell loss and impairs NaCl reabsorption in female mouse submandibular glands.

ABSTRACT: Slc4a11, a member of the Slc4 HCO3 - transporter family, has a wide tissue distribution. In mouse salivary glands, the expression of Slc4a11 mRNA was more than eightfold greater than the other nine members of the Slc4 gene family. The Slc4a11 protein displayed a diffuse subcellular distribution in both the acinar and duct cells of mouse submandibular glands (SMG). Slc4a11 disruption induced a significant increase in the Na+ and Cl- concentrations of stimulated SMG saliva, whereas it did not affect the fluid secretion rate in response to either β-adrenergic or cholinergic receptor stimulation. Heterologous expressed mouse Slc4a11 acted as a H+ /OH- transporter that was uncoupled of Na+ or Cl- movement, and this activity was blocked by ethyl-isopropyl amiloride (EIPA) but not 4,4'-Diisothioc

SUBMITTER: Yang NY 

PROVIDER: S-EPMC6908739 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature