Genetic influences on delayed reward discounting: A genome-wide prioritized subset approach.

ABSTRACT: Delayed reward discounting (DRD) is a behavioral economic measure of impulsivity that has been consistently associated with addiction. It has also been identified as a promising addiction endophenotype, linking specific sources of genetic variation to individual risk. A challenge in the studies to date is that levels of DRD are often confounded with prior drug use, and previous studies have also had limited genomic scope. The current investigation sought to address these issues by studying DRD in healthy young adults with low levels of substance use (N = 986; 62% female, 100% European ancestry) and investigating genetic variation genome-wide. The genome-wide approach used a prioritized subset design, organizing the tests into theoretically and empirically informed categories and apportioni

SUBMITTER: MacKillop J 

PROVIDER: S-EPMC6908809 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature