Selective microstructural integrity impairments of the anterior corpus callosum are associated with cognitive deficits in obstructive sleep apnea.

ABSTRACT:

Background

There is some evidence that obstructive sleep apnea (OSA) patients have white matter integrity abnormality in the corpus callosum (CC). However, whether the CC subregions are differentially affected in OSA is largely unknown.

Methods

Twenty patients with OSA and 24 well-matched healthy controls were enrolled and underwent diffusion tensor imaging (DTI) and clinical and cognitive assessments. DTI tractography was used to reconstruct the CC which was divided into five subregions. Intergroup differences in multiple diffusion metrics of each CC subregion and their correlations with clinical and cognitive parameters were tested.

Results

In comparison with healthy controls, OSA patients exhibited white matter integrity alterations in the anterior CC, characterize

SUBMITTER: Zhang B 

PROVIDER: S-EPMC6908858 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature