Resting-state functional connectivity modulates the BOLD activation induced by nucleus accumbens stimulation in the swine brain.

ABSTRACT:

Introduction

While the clinical efficacy of deep brain stimulation (DBS) the treatment of motor-related symptoms is well established, the mechanism of action of the resulting cognitive and behavioral effects has been elusive.

Methods

By combining functional magnetic resonance imaging (fMRI) and DBS, we investigated the pattern of blood-oxygenation-level-dependent (BOLD) signal changes induced by stimulating the nucleus accumbens in a large animal model.

Results

We found that diffused BOLD activation across multiple functional networks, including the prefrontal, limbic, and thalamic regions during the stimulation, resulted in a significant change in inter-regional functional connectivity. More importantly, the magnitude of the modulation was closely related to the stre

SUBMITTER: Cho S 

PROVIDER: S-EPMC6908867 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature