EEG time signature in Alzheimer´s disease: Functional brain networks falling apart.

ABSTRACT: Spontaneous mental activity is characterized by dynamic alterations of discrete and stabile brain states called functional microstates that are thought to represent distinct steps of human information processing. Electroencephalography (EEG) directly reflects functioning of brain synapses with a uniquely high temporal resolution, necessary for investigation of brain network dynamics. Since synaptic dysfunction is an early event and best correlate of cognitive status and decline in patients along Alzheimer's disease (AD) continuum, EEG microstates might serve as valuable early markers of AD. The present study investigated differences in EEG microstate topographies and parameters (duration, occurrence and contribution) between a large cohort of healthy elderly (n = 308) and memory clinic pat

SUBMITTER: Smailovic U 

PROVIDER: S-EPMC6909352 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature