Effect of high-dose vitamin C therapy on severe burn patients: a nationwide cohort study.

ABSTRACT: BACKGROUND:Vitamin C is a well-documented antioxidant that reduces oxidative stress and fluid infusion in high doses; however, the association between high-dose vitamin C and reduced mortality remains unclear. This study evaluates the effect of high-dose vitamin C in severe burn patients under two varying thresholds. METHODS:We enrolled adult patients with severe burns (burn index ≥ 15) who were registered in the Japanese Diagnosis Procedure Combination national inpatient database from 2010 to 2016. Propensity score matching was performed between patients who received high-dose vitamin C within 1 day of admission (vitamin C group) and those who did not (control group). High-dose vitamin C was defined as a dosage in excess of 10 g or 24 g within 2 days of admission. The primary outcome was

SUBMITTER: Nakajima M 

PROVIDER: S-EPMC6909452 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature