SATB1 establishes ameloblast cell polarity and regulates directional amelogenin secretion for enamel formation.

ABSTRACT:

Background

Polarity is necessary for epithelial cells to perform distinct functions at their apical and basal surfaces. Oral epithelial cell-derived ameloblasts at secretory stage (SABs) synthesize large amounts of enamel matrix proteins (EMPs), largely amelogenins. EMPs are unidirectionally secreted into the enamel space through their apical cytoplasmic protrusions, or Tomes' processes (TPs), to guide the enamel formation. Little is known about the transcriptional regulation underlying the establishment of cell polarity and unidirectional secretion of SABs.

Results

The higher-order chromatin architecture of eukaryotic genome plays important roles in cell- and stage-specific transcriptional programming. A genome organizer, special AT-rich sequence-binding protein 1 (SATB1),

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC6909472 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature