Identification of differentially expressed genes and signaling pathways involved in endometriosis by integrated bioinformatics analysis.

ABSTRACT: Endometriosis is a common gynecological disease characterized by the presence and growth of endometrial tissue outside the uterus, including the pelvis and abdominal cavity. This condition causes various clinical symptoms, such as non-menstrual pelvic pain, dysmenorrhea and infertility, seriously affecting the health and quality of life of women. To date, the specific mechanism and the key molecules of endometriosis remain uncertain. The purpose of the present study was to elucidate the mechanisms involved in the development and persistence of the disease. A number of mRNA expression profile datasets (namely GSE11691, GSE23339, GSE25628 and GSE78851) were downloaded from the Gene Expression Omnibus (GEO) database. These gene expression profiles were normalized, and the differentially expre

SUBMITTER: Dai FF 

PROVIDER: S-EPMC6909483 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature