Visit-to-visit variability of glycemia and vascular complications: the Hoorn Diabetes Care System cohort.

ABSTRACT:

Background

Glycemic variation has been suggested to be a risk factor for diabetes-related complications. Previous studies did not address confounding of diabetes duration, number of visits and length of follow-up. Here, we characterize glycemic variability over time and whether its relation to diabetes-related complications and mortality is independent from diabetes- and follow-up duration.

Materials and methods

Individuals with type 2 diabetes (n = 6770) from the Hoorn Diabetes Care System cohort were included in this study. The coefficient of variation (CV) was calculated over 5-year sliding intervals. People divided in quintiles based on their CV. Cox proportional hazard models were used to investigate the role of glycemic CV as risk factor in diabetes-related complicatio

SUBMITTER: Slieker RC 

PROVIDER: S-EPMC6909524 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature