CXCL12 is involved in α-synuclein-triggered neuroinflammation of Parkinson's disease.

ABSTRACT: BACKGROUND:The mechanisms underlying the pathogenesis and progression of Parkinson's disease (PD) remain elusive, but recent opinions and perspectives have focused on whether the inflammation process induced by microglia contributes to α-synuclein-mediated toxicity. Migration of microglia to the substantia nigra (SN) could precede neurodegeneration in A53T mice. We hypothesized that CXCL12 could be a mediator in the α-synuclein-induced migration of microglia. METHODS:After establishing appropriate animal and cell culture models, we explored the relationship between α-synuclein and CXCL12 in A53T mice, primary microglia, and BV-2 cell lines. We also explored the mechanisms of these interactions and the signaling processes involved in neuroinflammation. RESULTS:We confirmed the positive corr

SUBMITTER: Li Y 

PROVIDER: S-EPMC6909602 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature