Cross-Species Evidence of Interplay Between Neural Connectivity at the Micro- and Macroscale of Connectome Organization in Human, Mouse, and Rat Brain.

ABSTRACT: The mammalian brain describes a multiscale system. At the microscale, axonal, dendritic, and synaptic elements ensure neuron-to-neuron communication, and at the macroscale, large-scale projections form the anatomical wiring for communication between cortical areas. Although it is clear that both levels of neural organization play a crucial role in brain functioning, their interaction is not extensively studied. Connectome studies of the mammalian brain in cat, macaque, and human have recently shown that regions with larger and more complex pyramidal cells to have more macroscale corticocortical connections. In this study, we aimed to further validate these cross-scale findings in the human, mouse, and rat brain. We combined neuron reconstructions from the NeuroMorpho.org neuroarchitecture

SUBMITTER: Scholtens LH 

PROVIDER: S-EPMC6909781 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature