Differential Effects of Rapamycin on Glucose Metabolism in Nine Inbred Strains.

ABSTRACT: Studies in mice suggest that rapamycin has a negative impact on glucose homeostasis by inducing insulin resistance. However, results have been inconsistent and difficult to assess because the strains, methods of treatment, and analysis vary among studies. Using a consistent protocol, we surveyed nine inbred strains of mice for the effect of rapamycin on various aspects of glucose metabolism. Across all strains, rapamycin significantly delayed glucose clearance after challenge. However, rapamycin showed no main effect on systemic insulin sensitivity. Analysis of individual strains shows that rapamycin induced higher glucose values at 15 minutes post-challenge in 7/9 strains. However, only three strains show rapamycin-induced reduction in glucose clearance from 15 to 120 minutes. Although pa

SUBMITTER: Reifsnyder PC 

PROVIDER: S-EPMC6909913 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature