Choice of Reference Creatinine for Post-Traumatic Acute Kidney Injury Diagnosis.

ABSTRACT:

Background

Acute kidney injury (AKI) after trauma is associated with poor outcomes. According to current guidelines, a diagnosis of AKI should be made based on an increase in serum creatinine from a reference value. However, a true reference is often unknown in patients presenting with traumatic injury. The aim of this study was to determine the optimal reference creatinine estimate for post-traumatic AKI diagnosis and staging. The optimal reference estimate was defined by a high incidence, strong prognostic ability, and incrementality at each stage.

Study design

This was a cohort study of adult trauma patients (older than 16 years) requiring ICU admission between 2009 and 2018 (n = 8,026) at a single Level I trauma center. AKI was determined using the following 4 reference

SUBMITTER: Hatton GE 

PROVIDER: S-EPMC6909921 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature