Multigene panel predicting survival of patients with colon cancer.

ABSTRACT: Objective: The purpose of this study was to investigate multigene panel markers to predict long-term survival in patients with colon cancer. Methods and materials: GSE39582 was randomly divided into a training set and a validation set, while TCGA-COAD and GSE17536 were treated as two independent validation cohorts. Survival-associated genes were included in elastic net penalized Cox proportional hazards regression (ENCPH) model. Based on the results of the ENCPH, a multigene panel was constructed. We evaluated predictive performance of the multigene panel by univariate and multivariate survival analysis, and time-dependent ROC analysis. Results: A total of 1025 colon cancer patients were included in the study, and 94 genes were showed to be related with the overall survival of colon cancer

SUBMITTER: Li HD 

PROVIDER: S-EPMC6909949 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature