Impact of Induced Syncytia Formation on the Oncolytic Potential of Myxoma Virus.

ABSTRACT:

Introduction

Cancer has become one of the most critical health issues of modern times. To overcome the ineffectiveness of current treatment options, research is being done to explore new therapeutic modalities. One such novel treatment is oncolytic virotherapy (OV) which uses tumor tropic viruses to specifically target and kill malignant cells. While OV has shown significant promise in recent clinical trials, the therapeutic use of viruses poses a number of unique challenges. In particular, obtaining effective viral spread throughout the tumor microenvironment remains problematic. Previous work has suggested this can be overcome by forcing oncolytic viruses to induce syncytia formation.

Methods

In the current work, we generated a series of recombinant myxoma viruses expressi

SUBMITTER: Burton C 

PROVIDER: S-EPMC6910101 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature