Chaperone-like chiral cages for catalyzing enantio-selective supramolecular polymerization.

ABSTRACT: Cage catalysis has emerged as an important approach for mimicking enzymatic reactions by increasing the reaction rate and/or product selectivity of various types of covalent reactions. Here, we extend the catalytic application of cage compounds to the field of non-covalent molecular assembly. Acid-stable chiral imine cages are found to catalyze the supramolecular polymerization of porphyrins with an accelerated assembling rate and increased product enantioselectivity. Because the imine cages have a stronger interaction with porphyrin monomers and a weaker interaction with porphyrin assemblies, they can fully automatically detach from the assembled products without being consumed during the catalytic process. We reveal the kinetics of the auto-detachment of cages and the chirality growth of

SUBMITTER: Wang Y 

PROVIDER: S-EPMC6910136 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature