Developmental origin, functional maintenance and genetic rescue of osteoclasts.

ABSTRACT: Osteoclasts are multinucleated giant cells that resorb bone, ensuring development and continuous remodelling of the skeleton and the bone marrow haematopoietic niche. Defective osteoclast activity leads to osteopetrosis and bone marrow failure^1-9, whereas excess activity can contribute to bone loss and osteoporosis¹⁰. Osteopetrosis can be partially treated by bone marrow transplantation in humans and mice^11-18, consistent with a haematopoietic origin of osteoclasts^13,16,19 and studies that suggest that they develop by fusion of monocytic precursors derived from haematopoietic stem cells in the presence of CSF1 and RANK ligand^1,20. However, the developmental origin and lifespan of osteoclasts, and the mechanisms that ensure maintenance

SUBMITTER: Jacome-Galarza CE 

PROVIDER: S-EPMC6910203 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature