Healthy Tissue Uptake of ⁶⁸Ga-Prostate-Specific Membrane Antigen, ¹⁸F-DCFPyL, ¹⁸F-Fluoromethylcholine, and ¹⁸F-Dihydrotestosterone.

ABSTRACT: PET is increasingly used for prostate cancer (PCa) diagnostics. Important PCa radiotracers include ⁶⁸Ga-prostate-specific membrane antigen HBED-CC (⁶⁸Ga-PSMA), ¹⁸F-DCFPyL, ¹⁸F-fluoromethylcholine (¹⁸F-FCH), and ¹⁸F-dihydrotestosterone (¹⁸F-FDHT). Knowledge on the variability of tracer uptake in healthy tissues is important for accurate PET interpretation, because malignancy is suspected only if the uptake of a lesion contrasts with its background. Therefore, the aim of this study was to quantify uptake variability of PCa tracers in healthy tissues and identify stable reference regions for PET interpretation. Methods: A total of 232 PCa PET/CT scans from multiple hospitals was analyzed, including 87 ^68<

SUBMITTER: Jansen BHE 

PROVIDER: S-EPMC6910637 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature