MicroRNA-710 regulates multiple pathways of carcinogenesis in murine metastatic breast cancer.

ABSTRACT: Prior research has shown that critical differences between non-metastatic and metastatic tumor cells are at the level of microRNA. Consequently, harnessing these molecules for the treatment of metastatic cancer could have significant clinical impact. In the present study, we set out to identify metastasis-specific microRNAs which drive metastatic colonization of distant organs. Using a murine model of metastatic breast cancer, we employed a directed approach in which we screened for microRNAs that are differentially expressed between the primary tumors and metastatic lesions but concordantly expressed in all of the metastatic lesions irrespective of the tissue that is colonized. Of the identified targets, we focused on miR-710, which was consistently and significantly downregulated in the

SUBMITTER: Yoo B 

PROVIDER: S-EPMC6910689 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature