Extensive ERG11 mutations associated with fluconazole-resistant Candida albicans isolated from HIV-infected patients.

ABSTRACT:

Background and purpose

Azoles are preferred antifungal agents given their inexpensiveness, limited toxicity, and potentiality of oral administration. However, the extensive use of prophylactic azole therapy for chronic infections, especially in immunocompromised patients, has led to an increase in azole resistance, thereby rising health care costs. Fluconazole resistance is associated with poor clinical outcomes and the emergence of new infections. The present study aimed to investigate the mutations of ERG11 gene in fluconazole-resistant Candida albicans isolates.

Materials and methods

This study was conducted on 80 clinical samples collected from HIV-infected patients with suspected candidiasis in Tagore Medical College Hospital and Government Hospital of Tho

SUBMITTER: Paul S 

PROVIDER: S-EPMC6910709 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature